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Inventi Impact: Pathology

Articles

  • Inventi:hpt/26541/18
    The Role of Osteocalcin and Alkaline Phosphatase Immunohistochemistry in Osteosarcoma\nDiagnosis
    01-Jan-1970 Research 2018 : October - December
    Hasrayati Agustina, Ita Asyifa, Afiati Aziz, Bethy S Hernowo

    Background.The diagnosis of Osteosarcoma (OSA) is not always straightforward. OSA may resembleOther Primary Bone Tumours\n(OPBT). The diagnosis of osteosarcoma is sometimes difficult especially in a very small specimen. Immunohistochemistry is one of\nancillary testing types that can help the diagnosis of many tumours. The aimof this study was to evaluate the validity of Osteocalcin\n(OCN) and Alkaline Phosphatase (ALP) immunohistochemistry in discriminating OSA from OPBT. Method.This study included\n50 selected human primary bone tumours, 25 cases of OSA and 25 cases of OPBT. Immunohistochemical evaluation of OCN and\nALP was done for all cases.The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall\naccuracy were calculated. Result. The mean age of OSA and OPBT patients was 19.6 �± 13.6 and 40.0 �± 16.3 years, respectively.\nOsteocalcin was positive in 17/25 (68%) cases of OSA and 16/25 (64%) cases of OPBT (

    How to Cite this Article
    Hasrayati Agustina, Ita Asyifa, Afiati\nAziz, and Bethy S. Hernowo, â??The Role of Osteocalcin and\nAlkaline Phosphatase Immunohistochemistry in Osteosarcoma\nDiagnosis,â? Pathology Research International, vol. 2018, Article\nID 6346409, 5 pages, 2018. https://\ndoi.org/10.1155/2018/6346409, https://\ncreativecommons.org/licenses/by/4.0/.
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